Survival Strategies of Pathogenic Candida Species in Human Blood Show Independent and Specific Adaptations.

ABSTRACT: Only four species, Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis, together account for about 90% of all Candida bloodstream infections and are among the most common causes of invasive fungal infections of humans. However, virulence potential varies among these species, and the phylogenetic tree reveals that their pathogenicity may have emerged several times independently during evolution. We therefore tested these four species in a human whole-blood infection model to determine, via comprehensive dual-species RNA-sequencing analyses, which fungal infection strategies are conserved and which are recent evolutionary developments. The ex vivo infection progressed from initial immune cell interactions to nearly complete killing of a

SUBMITTER: Kammer P 

PROVIDER: S-EPMC7542370 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature