PET amyloid in normal aging: direct comparison of visual and automatic processing methods.

ABSTRACT: Assessment of amyloid deposits is a critical step for the identification of Alzheimer disease (AD) signature in asymptomatic elders. Whether the different amyloid processing methods impacts on the quality of clinico-radiological correlations is still unclear. We directly compared in 155 elderly controls with extensive neuropsychological testing at baseline and 4.5 years follow-up three approaches: (i) operator-dependent standard visual reading, (ii) operator-independent automatic SUVR with four different reference regions, and (iii) novel operator and region of reference-independent automatic Aβ-index. The coefficient of variance was used to examine inter-individual variability for each processing method. Using visually-established amyloid positivity as the gold standard, the area under th

SUBMITTER: Haller S 

PROVIDER: S-EPMC7542434 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature