Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes.

ABSTRACT: This Article describes the development of a stable Ni^IV complex that mediates C(sp²)-H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a Ni^IV-catalyzed C-H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving Ni^IV, Ni^III, and Ni^II intermediates.

SUBMITTER: Meucci EA 

PROVIDER: S-EPMC7542544 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature