Kinetics of CD4⁺ T Helper and CD8⁺ Effector T Cell Responses in Acute Dengue Patients.

ABSTRACT: Background: The protective or pathogenic role of T lymphocytes during the acute phase of dengue virus (DENV) infection has not been fully understood despite its importance in immunity and vaccine development. Objectives: This study aimed to clarify the kinetics of T lymphocyte subsets during the clinical course of acute dengue patients. Study design: In this hospital-based cohort study, 59 eligible Vietnamese dengue patients were recruited and admitted. They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from the hospital. Results: We described for the first time the kinetics of T cell response during the clinical course of DENV infection. Severe cases showed s

SUBMITTER: Manh DH 

PROVIDER: S-EPMC7542683 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature