Decreased intrinsic excitability of cerebellar Purkinje cells following optokinetic learning in mice.

ABSTRACT: The optokinetic response (OKR), a reflexive eye movement evoked by a motion of the visual field, is known to adapt its strength to cope with an environmental change throughout life, which is a type of cerebellum-dependent learning. Previous studies suggested that OKR learning induces changes in in-vivo spiking activity and synaptic transmission of the cerebellar Purkinje cell (PC). Despite the recent emphasis on the importance of the intrinsic excitability related to learning and memory, the direct correlation between the intrinsic excitability of PCs and OKR learning has not been tested. In the present study, by utilizing the whole-cell patch-clamp recording, we compared the responses of cerebellar PCs to somatic current injection between the control and learned groups. We found that the

SUBMITTER: Kim YG 

PROVIDER: S-EPMC7542746 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature