GeneSetCluster: a tool for summarizing and integrating gene-set analysis results.

ABSTRACT:

Background

Gene-set analysis tools, which make use of curated sets of molecules grouped based on their shared functions, aim to identify which gene-sets are over-represented in the set of features that have been associated with a given trait of interest. Such tools are frequently used in gene-centric approaches derived from RNA-sequencing or microarrays such as Ingenuity or GSEA, but they have also been adapted for interval-based analysis derived from DNA methylation or ChIP/ATAC-sequencing. Gene-set analysis tools return, as a result, a list of significant gene-sets. However, while these results are useful for the researcher in the identification of major biological insights, they may be complex to interpret because many gene-sets have largely overlapping gene contents. Additional

SUBMITTER: Ewing E 

PROVIDER: S-EPMC7542881 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature