Remarkable metabolic reorganization and altered metabolic requirements in frog metamorphic climax.

ABSTRACT:

Background

Metamorphic climax is the crucial stage of amphibian metamorphosis responsible for the morphological and functional changes necessary for transition to a terrestrial habitat. This developmental period is sensitive to environmental changes and pollution. Understanding its metabolic basis and requirements is significant for ecological and toxicological research. Rana omeimontis tadpoles are a useful model for investigating this stage as their liver is involved in both metabolic regulation and fat storage.

Results

We used a combined approach of transcriptomics and metabolomics to study the metabolic reorganization during natural and T3-driven metamorphic climax in the liver and tail of Rana omeimontis tadpoles. The metabolic flux from the apoptotic tail

SUBMITTER: Zhu W 

PROVIDER: S-EPMC7542913 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature