NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure.

ABSTRACT:

Background

The lung is an important target organ for hypoxia treatment, and hypoxia can induce several diseases in the body.

Methods

We performed transcriptome sequencing for the lungs of rats exposed to plateau hypoxia at 0 day and 28 days. Sequencing libraries were constructed, and enrichment analysis of the differentially expressed genes (DEGs) was implemented using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, experimental validation was executed by quantitative real-time PCR (qRT-PCR) and western blot.

Results

The results showed that the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway that was involved in immunity may play a crucial function in lung injury caused by plateau hypoxia.

SUBMITTER: Wang H 

PROVIDER: S-EPMC7542964 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature