Quantitative and Qualitative Perturbations of CD8⁺ MAITs in Healthy Mycobacterium tuberculosis-Infected Individuals.

ABSTRACT: CD8 T cells are considered important contributors to the immune response against Mycobacterium tuberculosis, yet limited information is currently known regarding their specific immune signature and phenotype. In this study, we applied a cell population transcriptomics strategy to define immune signatures of human latent tuberculosis infection (LTBI) in memory CD8 T cells. We found a 41-gene signature that discriminates between memory CD8 T cells from healthy LTBI subjects and uninfected controls. The gene signature was dominated by genes associated with mucosal-associated invariant T cells (MAITs) and reflected the lower frequency of MAITs observed in individuals with LTBI. There was no evidence for a conventional CD8 T cell-specific signature between the two cohorts. We, therefore,

SUBMITTER: Pomaznoy M 

PROVIDER: S-EPMC7543048 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature