UBC-9 Acts in GABA Neurons to Control Neuromuscular Signaling in C. elegans.

ABSTRACT: Regulation of excitatory to inhibitory signaling balance is essential to nervous system health and is maintained by numerous enzyme systems that modulate the activity, localization, and abundance of synaptic proteins. SUMOylation is a key post-translational regulator of protein function in diverse cells, including neurons. There, its role in regulating synaptic transmission through pre- and postsynaptic effects has been shown primarily at glutamatergic central nervous system synapses, where the sole SUMO-conjugating enzyme Ubc9 is a critical player. However, whether Ubc9 functions globally at other synapses, including inhibitory synapses, has not been explored. Here, we investigated the role of UBC-9 and the SUMOylation pathway in controlling the balance of excitatory cholinergic and inhib

SUBMITTER: Kreyden VA 

PROVIDER: S-EPMC7543134 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature