Preoperative serum circulating microRNAs as potential biomarkers for chronic postoperative pain after total knee replacement.

ABSTRACT:

Background

Chronic postoperative pain affects approximately 20% of patients with knee osteoarthritis after total knee replacement. Circulating microRNAs can be found in serum and might act as biomarkers in a variety of diseases. The current study aimed to investigate the preoperative expression of circulating microRNAs as potential predictive biomarkers for the development of chronic postoperative pain in the year following total knee replacement.

Methods

Serum samples, collected preoperatively from 136 knee osteoarthritis patients, were analyzed for 21 circulatory microRNAs. Pain intensity was assessed using a visual analog scale before and one year after total knee replacement. Patients were divided into a low-pain relief group (pain relief percentage <30%) and a high-pain

SUBMITTER: Giordano R 

PROVIDER: S-EPMC7543153 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature