Prolonged Low-Dose Methylprednisolone in Patients With Severe COVID-19 Pneumonia.

ABSTRACT:

Background

In hospitalized patients with coronavirus disease 2019 (COVID-19) pneumonia, progression to acute respiratory failure requiring invasive mechanical ventilation (MV) is associated with significant morbidity and mortality. Severe dysregulated systemic inflammation is the putative mechanism. We hypothesize that early prolonged methylprednisolone (MP) treatment could accelerate disease resolution, decreasing the need for intensive care unit (ICU) admission and mortality.

Methods

We conducted a multicenter observational study to explore the association between exposure to prolonged, low-dose MP treatment and need for ICU referral, intubation, or death within 28 days (composite primary end point) in patients with severe COVID-19 pneumonia admitted to Italian respiratory

SUBMITTER: Salton F 

PROVIDER: S-EPMC7543560 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature