Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens.

ABSTRACT:

Purpose

Irradiation-avoiding strategies have been used with relative success in the treatment of infants and young children with medulloblastoma. While advances in cancer genomics have significantly improved our understanding of the tumor biology of medulloblastoma allowing for improved prognostication and risk-stratification, the molecular subgroup-specific outcomes of infants and young children with medulloblastoma treated with irradiation-avoiding strategies remains unknown.

Methods

Molecular and clinical features of children with medulloblastoma treated with irradiation-avoiding strategies at Children's Hospital Los Angeles were analyzed. Molecular subgrouping of these patients was determined using a 31-gene TaqMan Low Density Array signature. Survival analyses were cond

SUBMITTER: Yeo KK 

PROVIDER: S-EPMC7543681 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature