Removal of Interictal MEG-Derived Network Hubs Is Associated With Postoperative Seizure Freedom.

ABSTRACT: Objective: To investigate whether MEG network connectivity was associated with epilepsy duration, to identify functional brain network hubs in patients with refractory focal epilepsy, and assess if their surgical removal was associated with post-operative seizure freedom. Methods: We studied 31 patients with drug refractory focal epilepsy who underwent resting state magnetoencephalography (MEG), and structural magnetic resonance imaging (MRI) as part of pre-surgical evaluation. Using the structural MRI, we generated 114 cortical regions of interest, performed surface reconstruction and MEG source localization. Representative source localized signals for each region were correlated with each other to generate a functional brain network. We repeated this procedure across three

SUBMITTER: Ramaraju S 

PROVIDER: S-EPMC7543719 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature