Immune cell landscape analysis reveals prognostic immune cells and its potential mechanism in squamous cell lung carcinoma.

ABSTRACT:

Background

Squamous cell lung carcinoma (LUSC) was closely associated with smoking which was known to have a distant immunosuppression effect. In this study, we aimed to explore the relationship between immune cells and clinical outcomes of LUSC patients with smoking history.

Methods

The immune cell infiltration and RNA expression profiles of LUSC patients were collected from The Cancer Genome Atlas (TCGA). Then, the correlation between immune cell infiltration and clinical characteristics was explored. According to the level of immune cell infiltration, LUSC patients with smoking history were divided into high or low group to screen the differentially expressed lncRNAs and mRNAs. The prediction of target genes was performed by miRanda. Finally, the prognostic value of a cer

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7543728 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature