The intracellular renin-angiotensin system: Friend or foe. Some light from the dopaminergic neurons.

ABSTRACT: The renin-angiotensin system (RAS) is one of the oldest hormone systems in vertebrate phylogeny. RAS was initially related to regulation of blood pressure and sodium and water homeostasis. However, local or paracrine RAS were later identified in many tissues, including brain, and play a major role in their physiology and pathophysiology. In addition, a major component, ACE2, is the entry receptor for SARS-CoV-2. Overactivation of tissue RAS leads several oxidative stress and inflammatory processes involved in aging-related degenerative changes. In addition, a third level of RAS, the intracellular or intracrine RAS (iRAS), with still unclear functions, has been observed. The possible interaction between the intracellular and extracellular RAS, and particularly the possible deleterious or be

SUBMITTER: Labandeira-Garcia JL 

PROVIDER: S-EPMC7543790 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature