Enhancement of a Heroin Vaccine through Hapten Deuteration.

ABSTRACT: The United States is in the midst of an unprecedented epidemic of opioid substance use disorder, and while pharmacotherapies including opioid agonists and antagonists have shown success, they can be inadequate and frequently result in high recidivism. With these challenges facing opioid use disorder treatments immunopharmacotherapy is being explored as an alternative therapy option and is based upon antibody-opioid sequestering to block brain entry. Development of a heroin vaccine has become a major research focal point; however, producing an efficient vaccine against heroin has been particularly challenging because of the need to generate not only a potent immune response but one against heroin and its multiple psychoactive molecules. In this study, we explored the consequence of regiosel

SUBMITTER: Belz TF 

PROVIDER: S-EPMC7544008 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature