Clinical Features and Genomic Characterization of Post-Colonoscopy Colorectal Cancer.

ABSTRACT:

Introduction

Some colorectal cancers (CRCs) may be missed during colonoscopies. We aimed to determine the clinicopathological, biological, and genomic characteristics of post-colonoscopy CRCs (PCCRCs).

Methods

Of the 1,619 consecutive patients with 1,765 CRCs detected between 2008 and 2016, 63 patients with 67 PCCRCs, when colonoscopies were performed 6-60 months before diagnosis, were recruited. After excluding patients with inflammatory bowel disease, familial polyposis syndrome, CRCs that developed from diminutive adenomatous polyps, and recurrent CRCs after endoscopic resection, 32 patients with 34 PCCRCs were enrolled. The lesions' clinicopathological features, mismatch repair proteins (MMRs), and genomic alterations were investigated.

Results

The overall PCCRC-5

SUBMITTER: Tanaka H 

PROVIDER: S-EPMC7544176 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature