Influenza A virus co-opts ERI1 exonuclease bound to histone mRNA to promote viral transcription.

ABSTRACT: Cellular exonucleases involved in the processes that regulate RNA stability and quality control have been shown to restrict or to promote the multiplication cycle of numerous RNA viruses. Influenza A viruses are major human pathogens that are responsible for seasonal epidemics, but the interplay between viral proteins and cellular exonucleases has never been specifically studied. Here, using a stringent interactomics screening strategy and an siRNA-silencing approach, we identified eight cellular factors among a set of 75 cellular proteins carrying exo(ribo)nuclease activities or involved in RNA decay processes that support influenza A virus multiplication. We show that the exoribonuclease ERI1 interacts with the PB2, PB1 and NP components of the viral ribonucleoproteins and is required fo

SUBMITTER: Declercq M 

PROVIDER: S-EPMC7544206 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature