Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations.

ABSTRACT: The visual responses of neurons in the primary visual cortex (V1) are influenced by the animal's position in the environment [1-5]. V1 responses encode positions that co-fluctuate with those encoded by place cells in hippocampal area CA1 [2, 5]. This correlation might reflect a common influence of non-visual spatial signals on both areas. Place cells in CA1, indeed, do not rely only on vision; their place preference depends on the physical distance traveled [6-11] and on the phase of the 6-9 Hz theta oscillation [12, 13]. Are V1 responses similarly influenced by these non-visual factors? We recorded V1 and CA1 neurons simultaneously while mice performed a spatial task in a virtual corridor by running on a wheel and licking at a reward location. By changing the gain that couples the wheel m

SUBMITTER: Fournier J 

PROVIDER: S-EPMC7544510 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature