Development and validation of two SCORE-based cardiovascular risk prediction models for Eastern Europe: a multicohort study.

ABSTRACT:

Aims

Cardiovascular disease (CVD) risk prediction models are used in Western European countries, but less so in Eastern European countries where rates of CVD can be two to four times higher. We recalibrated the SCORE prediction model for three Eastern European countries and evaluated the impact of adding seven behavioural and psychosocial risk factors to the model.

Methods and results

We developed and validated models using data from the prospective HAPIEE cohort study with 14 598 participants from Russia, Poland, and the Czech Republic (derivation cohort, median follow-up 7.2 years, 338 fatal CVD cases) and Estonian Biobank data with 4632 participants (validation cohort, median follow-up 8.3 years, 91 fatal CVD cases). The first model (recalibrated SCORE) used the same risk

SUBMITTER: Tillmann T 

PROVIDER: S-EPMC7544536 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature