Mass Spectrometric Profiling of Neuropeptides in Callinectes sapidus during Hypoxia Stress.

ABSTRACT: Oxygen (O₂) is a critical component of life; without proper O₂ levels, cells are unable to respire, meaning glucose cannot be utilized. Thus, hypoxia (low O₂ levels) is a well-documented stressor, especially in aquatic environments. Neuropeptides are a major class of regulators for stress-induced responses; however, their global expression changes during stress are not well characterized due to the natural complexity of the nervous system. Beyond being a neurological model organism, crustaceans are regularly exposed to hypoxia, making them a relevant system for this study. Several neuropeptide families, including orcokinins, RFamides, and allatostatin A-types, show dynamic dysregulation due to hypoxic stress. In particular, the brain showed the most dynamic

SUBMITTER: Buchberger AR 

PROVIDER: S-EPMC7544650 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature