Combined Immunoscore for Prognostic Stratification of Early Stage Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

To date, no combined immunoscore has been evaluated for prognostic stratification of early stage non-small-cell lung cancer (NSCLC). The main goal of this study was to investigate the prognostic impact of programmed death ligand 1 (PD-L1) expression and different immune cell components (CD4+, CD8+ T-lymphocytes, and CD68+ macrophages) in early stage NSCLC patients, distinguishing peritumoral (PT) and intratumoral (IT) localizations. The secondary aim was to identify a combined immunoscore to optimize the prognostic stratification of NSCLC patients.

Methods

This retrospective study included surgical specimens from consecutive chemo-naive stage II-III radically resected NSCLC patients. Immunohistochemistry was carried out to evaluate PD-L1 expression and to quantify

SUBMITTER: Boscolo A 

PROVIDER: S-EPMC7544833 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature