The Involvement of the Chemokine RANTES in Regulating Luminal Acidification in Rat Epididymis.

ABSTRACT:

Background

A complex interplay between different cell types in the epithelium leads to activation of the luminal acidifying capacity of the epididymis, a process that is crucial for sperm maturation and storage. Basal cells sense the luminal angiotensin II (ANG II) and stimulate proton secretion in clear cells through nitric oxide (NO). Our previous study has shown the chemokine regulated upon activation normal T-cell expressed and secreted (RANTES) was expressed in the F4/80 positive macrophages of human epididymis. The objective of this study was to explore the involvement of RANTES in regulating the luminal acidification in the rat epididymis.

Methods

The role of RANTES was investigated by in vivo perfusion with recombinant RANTES, Met-RANTES, and PBS of different

SUBMITTER: Feng X 

PROVIDER: S-EPMC7544837 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature