Repurposing drugs for treatment of SARS-CoV-2 infection: computational design insights into mechanisms of action.

ABSTRACT: The COVID-19 pandemic has negatively affected human life globally. It has led to economic crises and health emergencies across the world, spreading rapidly among the human population and has caused many deaths. Currently, there are no treatments available for COVID-19 so there is an urgent need to develop therapeutic interventions that could be used against the novel coronavirus infection. In this research, we used computational drug design technologies to repurpose existing drugs as inhibitors of SARS-CoV-2 viral proteins. The Broad Institute's Drug Repurposing Hub consists of in-development/approved drugs and was computationally screened to identify potential hits which could inhibit protein targets encoded by the SARS-CoV-2 genome. By virtually screening the Broad collection, using rati

SUBMITTER: Kandwal S 

PROVIDER: S-EPMC7544922 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature