Binding of raloxifene to human complement fragment 5a (^hC5a): a perspective on cytokine storm and COVID19.

ABSTRACT: Human C5a (^hC5a), one of the pro-inflammatory glycoproteins of the complement system is known to undergo production hyperdrive in response to stress and infection. ^hC5a has been associated with the pathogenesis of many chronic and acute diseases, due to its proven ability in triggering the 'cytokine storm', by binding to its cognate receptor C5aR, expressed in myriad of tissues. Given the pleiotropic downstream function of ^hC5a, it is logical to consider the ^hC5a or its precursors as potential drug targets, and thus, we have been rationally pursuing the idea of neutralizing the harmful effect of excessive ^hC5a, by implementing the repurposing strategies for FDA-approved drugs. Indeed, the proof of principle biophysical studies publishe

SUBMITTER: Mishra R 

PROVIDER: S-EPMC7544936 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature