SARS-CoV M^pro inhibitory activity of aromatic disulfide compounds: QSAR model.

ABSTRACT: The main protease (M^pro) of SARS-associated coronavirus (SARS-CoV) had caused a high rate of mortality in 2003. Current events (2019-2020) substantiate important challenges for society due to coronaviruses. Consequently, advancing models for the antiviral activity of therapeutic agents is a necessary component of the fast development of treatment for the virus. An analogy between anti-SARS agents suggested in 2017 and anti-coronavirus COVID-19 agents are quite probable. Quantitative structure-activity relationships for SARS-CoV are developed and proposed in this study. The statistical quality of these models is quite good. Mechanistic interpretation of developed models is based on the statistical and probability quality of molecular alerts extracted from SMILES. The novel, desig

SUBMITTER: Toropov AA 

PROVIDER: S-EPMC7544941 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature