In-silico screening of plant-derived antivirals against main protease, 3CL^pro and endoribonuclease, NSP15 proteins of SARS-CoV-2.

ABSTRACT: Novel Coronavirus or SARS-CoV-2 outbreak has developed a pandemic condition all over the world. The virus is highly infectious and spreads by human to human local transmission mode. Till date, there is no vaccination or drugs been approved for the treatment by the World Health Organisation. Henceforth, the discovery of the potential drugs is an urgent and utmost requirement for the medical fraternity. Since, the side effects of plant-derived compounds will be lower compared to synthetic/chemical drugs. The Main protease (3CL^pro or NSP5) and endoribonuclease (NSP15) proteins are necessity for viral replication and its survival in the host cell. In the present study, in-silico approach of drug development was used to search for potential antiviral plant-derived compounds as

SUBMITTER: Sharma A 

PROVIDER: S-EPMC7544953 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature