Exploring the SARS-CoV-2 structural proteins for multi-epitope vaccine development: an in-silico approach.

ABSTRACT:

Introduction

The ongoing life-threatening pandemic of coronavirus disease 2019 (COVID-19) has extensively affected the world. During this global health crisis, it is fundamentally crucial to find strategies to combat SARS-CoV-2. Despite several efforts in this direction and continuing clinical trials, no vaccine has been approved for it yet.

Methods

To find a preventive measure, we have computationally designed a multi-epitopic subunit vaccine using immuno-informatic approaches.

Results

The structural proteins of SARS-CoV-2 involved in its survival and pathogenicity were used to predict antigenic epitopes. The antigenic epitopes were capable of eliciting a strong humoral as well as cell-mediated immune response, our predictions suggest. The final vaccine was construct

SUBMITTER: Kumar A 

PROVIDER: S-EPMC7544969 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature