METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m⁶A Methylation in Oral Squamous Cell Carcinoma.

ABSTRACT: RNA modification plays an essential function in regulating gene expression and diverse biological processes. RNA modification enzyme methyltransferase-like 3 (METTL3) affects tumor progression by regulating the N⁶-methyladenosine (m⁶A) modification in the mRNAs of critical oncogenes or tumor suppressors, but its effect in oral squamous cell carcinoma (OSCC) remains unknown. In this study, we revealed that METTL3 was consistently upregulated in two OSCC cohorts, and high METTL3 expression was associated with poor prognosis. Functionally, cell proliferation, self-renewal, migration, and invasion ability in vitro and tumor growth and metastasis in vivo were decreased after METTL3 knockdown in OSCC cells. In contrast, the opposite results were obtained after METTL3 overex

SUBMITTER: Liu L 

PROVIDER: S-EPMC7544972 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature