Pathogenicity Factors of Genomic Islands in Intestinal and Extraintestinal Escherichia coli.

ABSTRACT: Escherichia coli is a versatile bacterial species that includes both harmless commensal strains and pathogenic strains found in the gastrointestinal tract in humans and warm-blooded animals. The growing amount of DNA sequence information generated in the era of "genomics" has helped to increase our understanding of the factors and mechanisms involved in the diversification of this bacterial species. The pathogenic side of E. coli that is afforded through horizontal transfers of genes encoding virulence factors enables this bacterium to become a highly diverse and adapted pathogen that is responsible for intestinal or extraintestinal diseases in humans and animals. Many of the accessory genes acquired by horizontal transfers form syntenic blocks and are recognized as genomic i

SUBMITTER: Desvaux M 

PROVIDER: S-EPMC7545054 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature