Cross-Sectional Transcriptional Analysis of the Aging Murine Heart.

ABSTRACT: Cardiovascular disease accounts for millions of deaths each year and is currently the leading cause of mortality worldwide. The aging process is clearly linked to cardiovascular disease, however, the exact relationship between aging and heart function is not fully understood. Furthermore, a holistic view of cardiac aging, linking features of early life development to changes observed in old age, has not been synthesized. Here, we re-purpose RNA-sequencing data previously-collected by our group, investigating gene expression differences between wild-type mice of different age groups that represent key developmental milestones in the murine lifespan. DESeq2's generalized linear model was applied with two hypothesis testing approaches to identify differentially-expressed (DE) genes, both betw

SUBMITTER: Greenig M 

PROVIDER: S-EPMC7545256 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature