An organosynthetic dynamic heart model with enhanced biomimicry guided by cardiac diffusion tensor imaging.

ABSTRACT: The complex motion of the beating heart is accomplished by the spatial arrangement of contracting cardiomyocytes with varying orientation across the transmural layers, which is difficult to imitate in organic or synthetic models. High-fidelity testing of intracardiac devices requires anthropomorphic, dynamic cardiac models that represent this complex motion while maintaining the intricate anatomical structures inside the heart. In this work, we introduce a biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by replicating the cardiac myofiber architecture of the left ventricle. The heart model is composed of organic endocardial tissue from a preserved explanted heart with intact intracardiac structures and an active synthetic myocardium that dri

SUBMITTER: Park C 

PROVIDER: S-EPMC7545316 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature