Ovarian Cancer Cells Promote Glycolysis Metabolism and TLR8-Mediated Metabolic Control of Human CD4⁺ T Cells.

ABSTRACT: An immunosuppressive microenvironment is a major obstacle for successful tumor immunotherapy. Elucidating the regulatory mechanisms of energy metabolism and functionality in CD4⁺ T cells will provide insights for the development of novel immunotherapies for ovarian cancer (OC). An Agilent microarray was used to detect differences in gene expression between peripheral CD4⁺ T cells from five OC patients and those from five healthy controls. Functional pathway analysis was performed for differentially expressed genes. Gene expression profiles revealed significant differences in expression levels of 5,175 genes in peripheral CD4⁺ T cells from five patients with OC. Functional analysis indicated that the most significantly enriched pathways were metabolic pathwa

SUBMITTER: Shang W 

PROVIDER: S-EPMC7545320 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature