Association of Measurable Residual Disease With Survival Outcomes in Patients With Acute Myeloid Leukemia: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Measurable residual disease (MRD) refers to neoplastic cells that cannot be detected by standard cytomorphologic analysis. In patients with acute myeloid leukemia (AML), determining the association of MRD with survival may improve prognostication and inform selection of efficient clinical trial end points.

Objective

To examine the association between MRD status and disease-free survival (DFS) and overall survival (OS) in patients with AML using scientific literature.

Data sources

Clinical studies on AML published between January 1, 2000, and October 1, 2018, were identified via searches of PubMed, Embase, and MEDLINE.

Study selection

Literature search and study screening were performed according to the Preferred Reporting Items for Systematic Reviews

SUBMITTER: Short NJ 

PROVIDER: S-EPMC7545346 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature