Elevated Circulating Fetuin-B Levels Are Associated with Insulin Resistance and Reduced by GLP-1RA in Newly Diagnosed PCOS Women

ABSTRACT:

Background

Previous studies have suggested that Fetuin-B seems to be a secreted adipokine related to metabolic diseases. However, the results have been inconsistent. Here, our objective is to investigate the changes in circulating Fetuin-B levels in women with polycystic ovary syndrome (PCOS) and analyze the association of Fetuin-B and insulin resistance (IR).

Methods

The current study is comprised of a cross-sectional study and a series of interventional studies. Oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamp (EHC) were engaged to assess glucose tolerance and insulin sensitivity. Serum Fetuin-B levels were determined by ELISA.

Results

Serum Fetuin-B and TNF-α levels were markedly increased in women with PCOS compared to healthy women

SUBMITTER: Mokou M 

PROVIDER: S-EPMC7545451 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature