Shallow Distance Dependence for Proton-Coupled Tyrosine Oxidation in Oligoproline Peptides.

ABSTRACT: We have explored the kinetic effect of increasing electron transfer (ET) distance in a biomimetic, proton-coupled electron-transfer (PCET) system. Biological ET often occurs simultaneously with proton transfer (PT) in order to avoid the high-energy, charged intermediates resulting from the stepwise transfer of protons and electrons. These concerted proton-electron-transfer (CPET) reactions are implicated in numerous biological ET pathways. In many cases, PT is coupled to long-range ET. While many studies have shown that the rate of ET is sensitive to the distance between the electron donor and acceptor, extensions to biological CPET reactions are sparse. The possibility of a unique ET distance dependence for CPET reactions deserves further exploration, as this could have implications for h

SUBMITTER: Koronkiewicz B 

PROVIDER: S-EPMC7545454 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature