Metabolic Effects of Testosterone Replacement Therapy in Patients with Type 2 Diabetes Mellitus or Metabolic Syndrome: A Meta-Analysis.

ABSTRACT:

Background

Testosterone replacement therapy (TRT) is commonly used for the treatment of hypogonadism in men, which is often associated with type 2 diabetes mellitus (T2DM) and metabolic syndrome (Mets). Recent compiling evidence shows that TRT has beneficial metabolic effects on these patients.

Objective

A meta-analysis has been conducted to evaluate the effects of TRT on cardiovascular metabolic factors.

Methods

We conducted a systemic search on PubMed, Embase, Cochrane Library, Wanfang, and CNKI and selected randomized controlled trials (RCTs) to include. The efficacy of TRT on glycemia, insulin sensitivity, lipid profile, and body weight was meta-analyzed by Review Manager.

Results

A total of 18 RCTs, containing 1415 patients (767 in TRT and 648 in control),

SUBMITTER: Li SY 

PROVIDER: S-EPMC7545471 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature