Bloodstream Infections and Delayed Antibiotic Coverage Are Associated With Negative Hospital Outcomes in Hematopoietic Stem Cell Transplant Recipients.

ABSTRACT:

Background

Bloodstream infections (BSIs) are common after hematopoietic stem cell transplantation (HSCT) and are associated with increased long-term morbidity and mortality. However, short-term outcomes related to BSI in this population remain unknown. More specifically, it is unclear whether choices related to empiric antimicrobials for potentially infected patients are associated with patient outcomes.

Research question

Are potential delays in appropriate antibiotics associated with hospital outcomes among HSCT recipients with BSI?

Study design and methods

We conducted a retrospective cohort study at a large comprehensive inpatient academic cancer center between January 2014 and June 2017. We identified all admissions for HSCT and prior recipients of HSCT. We define

SUBMITTER: Ji J 

PROVIDER: S-EPMC7545481 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature