White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition.

ABSTRACT:

Background

White matter hyperintensities (WMH) are very frequent in older adults and associated with worse cognitive performance. Little is known about the links between WMH and vascular risk factors, cortical β-amyloid (Aβ) load, and cognition in cognitively unimpaired adults across the entire lifespan, especially in young and middle-aged adults.

Methods

One hundred and thirty-seven cognitively unimpaired adults from the community were enrolled (IMAP cohort). Participants underwent (i) a comprehensive neuropsychological assessment of episodic memory, processing speed, working memory, and executive functions; (ii) brain structural T1 and FLAIR MRI scans used for the automatic segmentation of total and regional (frontal, parietal, temporal, occipital, and corpus callosum) WMH

SUBMITTER: Garnier-Crussard A 

PROVIDER: S-EPMC7545576 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature