Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India.

ABSTRACT: Studies on host-pathogen interaction have identified human ACE2 as a host cell receptor responsible for mediating infection by coronavirus (COVID-19). Subsequent studies have shown striking difference of allele frequency among Europeans and Asians for a polymorphism rs2285666, present in ACE2. It has been revealed that the alternate allele (TT-plus strand or AA-minus strand) of rs2285666 elevate the expression level of this gene upto 50%, hence may play a significant role in SARS-CoV-2 susceptibility. Therefore, we have first looked the phylogenetic structure of rs2285666 derived haplotypes in worldwide populations and compared the spatial frequency of this particular allele with respect to the COVID-19 infection as well as case-fatality rate in India. For the first time, we ascerta

SUBMITTER: Srivastava A 

PROVIDER: S-EPMC7545580 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature