Associations of sleep characteristics with alpha-synuclein in cerebrospinal fluid in older adults.

ABSTRACT:

Objective

Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha-synuclein in the brain, which was indicated by alpha-synuclein levels in cerebrospinal fluid (CSF). We aimed to investigate associations of sleep characteristics with CSF alpha-synuclein in older adults.

Methods

Our study recruited 536 cognitively intact individuals (aged between 40 and 90 years old) from the Chinese Alzheimer's Biomarker and Lifestyle study. Sleep behaviors were assessed by Pittsburgh Sleep Quality Index and total alpha-synuclein in CSF was measured by enzyme-linked immune-sorbent assay. We used multiple linear and non-linear regression models for research.

Results

Signif

SUBMITTER: Wang XT 

PROVIDER: S-EPMC7545588 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature