Correlates of polyneuropathy in Parkinson's disease.

ABSTRACT:

Objective

Previous studies in Parkinson's disease (PD) patients have demonstrated a high prevalence of polyneuropathy (PNP) and pronounced alpha-Synuclein pathology in dermal nerve fibers already at early disease stages. The aim of this study was to analyze associations between the prevalence and severity of PNP with nonmotor and motor symptoms in PD patients.

Methods

Fifty PD patients were characterized comprehensively for the presence of clinical symptoms (nonmotor and motor), electrophysiologic alterations and - for the first time - using high-resolution ultrasound of peripheral nerves.

Results

Sixty-two percent of PD patients showed electrophysiological pathology of PNP. The prevalence of patient-reported PNP symptoms was 86% and was particularly present in patien

SUBMITTER: Kuhn E 

PROVIDER: S-EPMC7545593 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature