Association of serum Apolipoprotein B with cerebrospinal fluid biomarkers of Alzheimer's pathology.

ABSTRACT:

Objective

To examine whether apolipoprotein B (ApoB), apolipoprotein A-1 (ApoA1), or their ratio (ApoB/A1) were associated with early changes in cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) pathology in elderly adults with subjective cognitive decline (SCD).

Methods

This study included 507 objective cognitive normal participants from the Chinese Alzheimer's Biomarker and LifestylE (CABLE) database including 288 cognitive normal participants (CN) and 219 SCD. Multiple linear regression models were used to examine the associations of apolipoproteins with CSF AD biomarkers.

Results

Compared with control group, SCD participants with significant AD biological characteristics had lower ApoB levels (P = 0.0461). In total participants, lower level of serum

SUBMITTER: Hu H 

PROVIDER: S-EPMC7545610 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature