Neurodegeneration trajectory in pediatric and adult/late DM1: A follow-up MRI study across a decade.

ABSTRACT:

Objective

To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential predictive markers of such progression.

Methods

21 DM1 patients (pediatric onset: N = 9; adult/late onset: N = 12) and 18 healthy controls (HC) were assessed longitudinally over 9.17 years through brain MRI. Additionally, patients underwent neuropsychological, genetic, and muscular impairment assessment. Inter-group comparisons of total and voxel-level regional brain volume were conducted through Voxel Based Morphometry (VBM); cross-sectionally and longitudinally, analyzing the associations between brain changes and demographic, clinical, and cognitive outcomes.

Results

The percentage of GM loss did not sign

SUBMITTER: Labayru G 

PROVIDER: S-EPMC7545612 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature