Altered coupling between resting-state glucose metabolism and functional activity in epilepsy.

ABSTRACT:

Objective

Altered functional activities and hypometabolism have been found in medial temporal lobe epilepsy patients with hippocampal sclerosis (mTLE-HS). Hybrid PET/MR scanners provide opportunities to explore the relationship between resting-state energy consumption and functional activities, but whether repeated seizures disturb the bioenergetic coupling and its relationship with seizure outcomes remain unknown.

Methods

¹⁸ F-FDG PET and resting-state functional MRI (rs-fMRI) scans were performed with hybrid PET/MR in 26 patients with mTLE-HS and in healthy controls. Energy consumption was quantified by ¹⁸ F-FDG standardized uptake value ratio(SUVR) relative to cerebellum. Spontaneous neural activities were estimated using regional homogeneity (ReHo),

SUBMITTER: Wang J 

PROVIDER: S-EPMC7545617 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature