Prognostic alternative splicing signature reveals the landscape of immune infiltration in Pancreatic Cancer.

ABSTRACT: Background: Pancreatic cancer (PC) is an aggressive cancer with worse survival in the world. Emerging evidence suggested that the imbalance of alternative splicing (AS) is a hallmark of cancer and indicated poor prognosis of patients. Genes-derived splicing events can produce neoepitopes for immunotherapy. However, the profound study of splicing profiling in PC is still elusive. We aimed to identification of novel prognostic signature across a comprehensive splicing landscape and reveal their relationship with tumor-infiltrating immune cells in pancreatic cancer microenvironment. Methods: Based on integrated analysis of splicing profiling and clinical data, differentially splicing events were filtered out. Then, stepwise Cox regression analysis was applied to identify surviva

SUBMITTER: Wang L 

PROVIDER: S-EPMC7545682 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature