Plasma Aβ and neurofilament light chain are associated with cognitive and physical function decline in non-dementia older adults.

ABSTRACT:

Background

Cognition is closely associated with physical function. Although high brain amyloid-β (Aβ) deposition and neurofilament light chain (NfL) are associated with cognitive and gait speed decline, relationships of combined plasma Aβ and NfL profiles with cognitive and physical functions in older adults remain unknown. The research aim of this study was to investigate the prospective associations of combined plasma Aβ and NfL profiles with cognitive and physical functions in older adults.

Methods

Participants (n = 452, aged 76 ± 5 years) who had both plasma Aβ and NfL data collected from the Multidomain Alzheimer's Preventive Trial (MAPT, May 2008 to April 2016) were included in the current study. These participants were from four MAPT groups (multidomain interventions

SUBMITTER: He L 

PROVIDER: S-EPMC7545881 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature