Comparative host-pathogen protein-protein interaction analysis of recent coronavirus outbreaks and important host targets identification.

ABSTRACT: Last two decades have witnessed several global infectious outbreaks. Among these, coronavirus is identified as a prime culprit ranging from its involvement in severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) to COVID-19. These infections involved in huge healthcare and economic cost incurred globally. Every time, coronavirus improved its infection ability and surprised the medical practitioners and researchers. Currently, COVID-19 is also causing numerous infections and stalled global activities. Global efforts are underway to identify potential viral targets for management of these outbreaks, but significant progress in prevention of these outbreaks is not yet achieved. We explored host-pathogen protein-protein interactions of MERS, SARS and COVID-19, and

SUBMITTER: Khan AA 

PROVIDER: S-EPMC7546044 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature