Automatic Quantification of Interstitial Lung Disease From Chest Computed Tomography in Systemic Sclerosis.

ABSTRACT: Background: Interstitial lung disease (ILD) is a common complication in patients with systemic sclerosis (SSc), and its diagnosis contributes to early treatment decisions. Purposes: To quantify ILD associated with SSc (SSc-ILD) from chest CT images using an automatic quantification method based on the computation of the weight of interstitial lung opacities. Methods: Ninety-four patients with SSc underwent CT, forced vital capacity (FVC), and carbon monoxide diffusion capacity (DL_CO) tests. Seventy-three healthy individuals without radiological evidence of lung disease served as controls. After lung and airway segmentation, the ratio between the weight of interstitial opacities [densities between -500 and +50 Hounsfield units (HU)] and the total lung weight

SUBMITTER: Carvalho ARS 

PROVIDER: S-EPMC7546366 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature